A recent study indicates that patients who stop using new GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds far faster than those who end conventional diet and exercise programs.
Research printed in a prominent medical journal demonstrates that while overweight individuals can lose substantial amounts of their total mass while undergoing treatment, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals using such medications should be cognizant of the potential of rapid rebound weight gain when the treatment is stopped," stated expert Dr. Susan Jebb.
Such speed of recovery implies a return to starting weight within about one and a half years.
Analyzing Therapies
The research, which examined dozens of trials involving over 9,000 of patients, compared the outcomes of the injectable medications with older methods.
Scientists point out that individuals who lose weight through dieting generally have a less rapid weight regain—approximately 100 grams monthly—once they finish.
The Reason for the Rapid Rebound
Doctors propose the mode of action of the injections is key to understanding the amplified rebound.
GLP-1 drugs imitate a body's own chemical called glucagon-like peptide-1, which moderates appetite.
"Artificially providing the hormone concentrations far above than normal may cause the body to generate a reduced amount of its own natural GLP-1, and may also diminish responsiveness to its effects," said Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this GLP-1 'fix' results in hunger is no longer kept in check, making binge eating a significant risk."
A Chronic Issue?
The NHS suggest the injections for people with obesity-related health risks, alongside prescribed diet and exercise modifications.
A number of clinicians argue that, given the high risk of relapse, the therapy is often life-long.
This perspective is supported by pharmaceutical companies, who note that the results "underscore the long-term nature of excess weight," comparing it to managing conditions like high blood pressure.
Patient Accounts
People who have stopped the jabs report a intense return of hunger.
"It felt as if a trigger activating and I was suddenly extremely hungry," described an individual.
This challenge is exacerbated if patients have not adopted permanent lifestyle or habit changes during treatment.
Growing Adoption
Figures show that millions of people in the UK have used weight-loss jabs in the past year, with desire remaining high.
- Adoption is higher among females compared to men.
- The middle-aged age group shows the highest usage rates.
- Many obtain the drugs through private prescriptions rather than the NHS.
Finally, researchers stress that while these medications are effective agents for shedding pounds, they are not a permanent solution and lasting health benefits relies on combined behavioural management.
